Hypersensitivity reaction to dapsone: report from Malaysia.

Three patients who developed hypersensitivity reaction at varying intervals after the initiation of dapsone therapy are described. Two of them had leprosy whereas the other had dermatitis herpetiformis. Their clinical manifes­ tations were not uniform. Although fatal complications have been reported, the unique role played by dapsone in the treatment of leprosy and the importance of recognizing this reaction are discussed.